Return to Directory

Stuart A. Allison

Professor    Associate Chair    
Education

B.A. (1973): University of Montana
M.S. (1976) : University of California at Berkeley
Ph.D. (1980) : University of Washington
NIH Fellowship (1981-1982) : University of Oregon

Specializations

Biophysical Chemistry

Biography

The S. Allison laboratory is primarily interested in biomolecular transport with particular emphasis in the theory of diffusion, viscosity, and electrophoresis. We have focused on detailed modeling of transport with the objective of learning what electrophoresis, diffusion, and viscosity can tell us about biomolecular charge, conformation, and structure. Over the last few years, we have shown that detailed modeling can accurately predict the electrophoretic mobilities of large classes of peptides and, in specific cases, can be used to address conformational questions as well. Modeling of electrophoresis has been carried out both in free solution and in a gel. Modeling in a gel presents particular challenges and it is in that area where current research is concentrated.

 

INVITED SEMINARS or TALKS (since 2000)

“Boundary Element Modeling of Biomolecular Transport”, University of Glasgow, Glasgow, Scotland, UK, 9/00

“Transport Properties of Colloids and Macroions Using Detailed Models,”  University of Goteborg, Goteborg, Sweden, 4/02

“Electrokinetic Modeling of Protein Charge Ladders,”  Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, 9/04

“Modeling the Electrophoretic Mobility of Peptides and Proteins in Aqueous Solution,” Southeast Theoretical Chemistry Association (SETCA), Annual Meeting, Emory University, Atlanta, GA., 5/19-20/06.

 

SIGNIFICANT INSTITUTIONAL SERVICE (since 2000)

Departmental Curriculum Committee, 1994-present

Departmental Executive Committee, 1999-2002

Departmental Bioinformatics Advisor, 2002-present

College Promotion & Tenure Committee, 2000-2003

College of Arts and Sciences Executive Committee, 2006-present

Publications

Representative Publications

  1. H. Wu, U. Twahir, A.N. Davis, E. Duodu, B. B. Kashani, Y.K. Lee, C. Pena, N. Whitley, S.A. Allison, “Rotational Diffusion of Macromolecules and Nanoparticles Modeled as non Overlapping Bead Arrays in an Effective Medium,” Polymers 3 846-860 (2011).
  2. S.A. Allison, “Modeling the Free Solution Electrophoresis of Ions and Macroions,” (invited review article) Encyclopedia of Surface and Colloid Science, Second Edition, 1-14 (2012).
  3. H. Wu, S.A. Allison, C. Perrin, and H. Cottet, “Modeling the Electrophoresis of Highly Charged Peptides: Application to Oligolysines”, J. Sep. Sci., 35 556-562 (2012).
  4. A. Ibrahim, H. Ohshima, S.A. Allison, H. Cottet, “Determination of Effective Charge of Small Ions, Polyelectrolytes, and Nanoparticles by Capillary Electrophoresis,” Journal of Chromatography A, 1247, 154-461 (2012).
  5. A. Ibrahim, S.A. Allison, H. Cottet, “Extracting Information from the Ionic Strength Dependence of Electrophoretic Mobility by Use of Slope Plot,” Analytical Chemistry, 84 , 9422-9430 (2012).