Columbia University, Postdoctoral, 2018, Biology
University of Georgia, Ph.D., 2013, Neuroscience
University of Georgia, M.S., 2010, Psychology
University of Georgia, B.A., 2008, Philosophy
Two-photon calcium imaging
Jordan Hamm was born in upstate New York, later moved to Atlanta, and then attended the University of Georgia for his undergraduate degree in philosophy (2004-2008). He stayed for his Ph.D. in neuroscience under the mentorship of Dr. Brett Clementz. Here he studied human populations with bipolar disorder and SZ, carrying out electro/magnetoencephalography (E/MEG) and multivariate analyses (K-means, PCA, Joint-ICA) of large multimodal datasets (MRI, EEG, genetics, behavior). Findings from this work emphasized the utility of studying neuroimaging “biomarkers” as translational and quantitative tools for the revision of diagnostic categories in psychiatry. As a result, Dr. Hamm developed an interest in how these EEG biomarkers relate to underlying neurobiological disease processes, a topic impossible to address with non-invasive human neuroscience methods alone. He sought out a postdoctoral position in Rafael Yuste’s laboratory at Columbia University, where he transitioned to studying cortical function with cellular precision in awake mice. Dr. Hamm was trained in state-of-the-art tools such as two-photon calcium imaging (2P-Ca++), opto/chemicogenetics, and multi-electrode recordings, and developed his own research program aimed at mapping specific domains of dysfunction in a psychiatric population (i.e. sensory processing dysfunction) from biomarkers and behaviors to cells and circuits.
The Hamm lab conducts basic research on cortical microcircuitry with paradigms and approaches designed to provide deeper insight into neuropsychiatric disease. Sensory processing abnormalities in schizophrenia (SZ) undermine how affected individuals perceive and relate to a changing environment. These aberrations reflect fundamental neural pathophysiology in SZ, impacting stable information processing and giving rise to downstream deficits in cognitive and social functioning. Dr. Hamm’s research focuses on the interaction between the cellular, circuit-level, and networks of function in the cortex i) as it relates to sensory processing dysfunction specifically, and ii) as it can provide clues toward a unifying pathophysiology in this very heterogeneous disease. His laboratory will employ techniques such as 2P-Ca++, dense array local field potential recordings (LFP/CSD), and opto/chemicogenetics in awake, behaving mice, utilizing both wild-type mice and mouse models of SZ relevant disease processes. Critically, sensory cortical structure and function is relatively well-conserved across mammals, and is highly accessible with classic psychophysical and neuroscience approaches. The Hamm lab takes advantage of this fact, employing paradigms which can be employed with human patients in clinical settings and rodent models in the lab, whereby established disease “biomarkers” (e.g. EEG measures) can be linked with specific neurobiology and therapeutics.
2019-22, “Mapping the role of basal forebrain projections to visual cortex in novelty processing”, Whitehall Foundation, PI: J.P. Hamm ($225,000 Direct)
2017-22, “Fronto-sensory circuit mechanisms of perceptual novelty processing”, NIMH 1K99MH115082, PI: J.P. Hamm. Sponsor: R. Yuste. Consultants: A. Churchland; J. Gogos ($950,000 Direct).
2016-17, “Translational neurophysiology of neuropsychiatric disorders: leveraging the BRAIN initiative” Interdisciplinary Research Initiatives Seed (IRIS) funding program, Columbia University. PI: D. Javitt. Co-PI: J.P. Hamm, R. Yuste. ($100,000)
2014-17, “Two-photon analysis of circuit-level mechanisms of schizophrenia biomarkers”, NIMH F32MH106265, PI: J.P. Hamm. Mentor: R. Yuste. Co-mentors: D. Javitt, J. Gordon. ($155,000)
Hamm, J.P., Peterka, D.S., Gogos, J.A., Yuste, R. (2017) Altered cortical ensembles in mouse models of schizophrenia. Neuron. 94, 1, 153–167
Hamm, J.P., Yuste, R. (2016). Somatostatin Interneurons Control a Key Component of Mismatch Negativity in Mouse Visual Cortex. Cell Reports. 16, 407–420
Clementz, B.A., Sweeney, J.A., Hamm, J.P., Ivleva, E.I., Ethridge, L.E., Pearlson, G.D., Keshavan, M.S., Tamminga, C.A. (2016). Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers. American Journal of Psychiatry. 173(4):373-84
Hamm, J.P., Oliver, W.T., Hudgens-Haney, M., Bobilev, A., McDowell, J.E., Buckley, P.F., Clementz, B.A. (2015). Stimulus Train Duration but Not Attention Moderates γ-band Entrainment Abnormalities in Schizophrenia. Schizophrenia Research. 165(1):97-102
Hamm, J.P., Dyckman, K.A., McDowell, J.E., Clementz, B.A. (2012) Pre-cue Fronto-Occipital Alpha Phase and Distributed Cortical Oscillations Predict Failures of Cognitive Control. Journal of Neuroscience. 2(20):7034-41
Hamm, J.P., Gilmore, C.S., Picchetti, N, Sponheim, S.R., and Clementz, B.A. (2011). Abnormalities of Neuronal Oscillations and Temporal Integration to Low and High Frequency Auditory Stimulation in Schizophrenia. Biological Psychiatry. 69(10):989-96